Notch in T-ALL: new players in a complex disease.

نویسندگان

  • Ute Koch
  • Freddy Radtke
چکیده

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic malignancy of thymocytes affecting preferentially children and adolescents. The disease is heterogeneous and characterized by a large set of chromosomal and genetic alterations that deregulate the growth of maturing thymocytes. The identification of activating point mutations in NOTCH1 in more then 50% of all T-ALL cases highlights the NOTCH1 cascade as a central player of T-ALL pathogenesis. In this review, we summarize and update more recent findings on the molecular mechanisms of T-ALL with a particular emphasis on the oncogenic properties of aberrant NOTCH1 signaling.

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عنوان ژورنال:
  • Trends in immunology

دوره 32 9  شماره 

صفحات  -

تاریخ انتشار 2011